Nitric Oxide Opens ATP-sensitive K + Channels through Suppression of Phosphofructokinase Activity and Inhibits Glucose-induced Insulin Release in Pancreatic 13 Cells
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Address correspondence to Dr. Yoshiyuki Tsuura, Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606, Japan. j. GEN. PHYSIOL. 9 The Rockefeller University Press 9 0022-1295/94/12/1079/21 $2.0
منابع مشابه
Nitric oxide opens ATP-sensitive K+ channels through suppression of phosphofructokinase activity and inhibits glucose-induced insulin release in pancreatic beta cells
Nitric oxide (NO) is known to be a potent messenger in the intracellular signal transduction system in many tissues. In pancreatic beta cells, NO has been reported to be formed from L-arginine through NO synthase. To elucidate the effect of NO on insulin secretion and to investigate the intracellular mechanism of its effect, we have used sodium nitroprusside (SNP) as a NO donor. SNP inhibited g...
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